The Court of Cassation ruled that a Florence appeals court must re-try the case against Knox and her Italian ex-boyfriend for the 2007 murder of 21-year-old Meredith Kercher.
The University of Washington student stayed up until 2 a.m. PDT to hear the ruling and subsequently issued a statement.
“It was painful to receive the news that the Italian Supreme Court decided to send my case back for revision when the prosecution’s theory of my involvement in Meredith’s murder has been repeatedly revealed to be completely unfounded and unfair,” the statement said.
Knox said the case must now be subjected to “an objective investigation and a capable prosecution.”
“No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity,” Knox said in the statement.
Kercher’s dead body was discovered in November 2007 in a bedroom of the house she shared with Knox and others in Perugia, where the two were exchange students. Kercher’s throat had been slashed.
Prosecutors claim that Kercher was the victim of a drug-induced sex party gone terribly wrong. Knox and Raffaele Sollecito have denied any wrongdoing in the matter and say they were not even present in the apartment that night.
Rudy Guede, a man from the Ivory Coast, was convicted in a separate trial and is currently serving a 16-year sentence. Knox and Sollecito were also initially convicted and given hefty prison sentences, but were then acquitted on appeal in 2011.
The high court’s decision on Tuesday overturned the acquittals from the appeals court.