The two right westbound lanes of Route 50 at Baydale Drive near Sandy Point had to be closed while the accident was cleared.
Maryland State Police said that other vehicles were involved in the crash, which took place just after 5:30 a.m. ET.
The tractor trailer reportedly had a load of about 20 crushed cars on it .
A 50-year-old man was taken to Shock Trauma with serious but non-life threatening injuries.