Police say the fatal crash took place just after 11 a.m. ET along Route 31 near the intersection with Wakefield Valley Road in New Windsor, Maryland.
There, a tractor trailer reportedly collided with another car.
One person from the car is dead and medical personnel took another victim to the hospital with minor injuries.
Route 31 will be shut down for “an extended period of time,” according to authorities.
This section of the roadway near Wakefield Valley Road has been closed in both directions as the investigation continues.