Police in Baltimore City say officers were making a routing traffic stop when one of the two people in the automobile resisted arrest.
The incident took place along Kitmore Road in northeastern Baltimore.
There was reportedly an altercation between at least one officer and the man who reportedly was resisting arrest.
Witnesses say officers were seen beating the man with their batons and spraying him with pepper spray.
One of the officers then called for help before realizing the man had gone into cardiac arrest.
The man was taken to an area hospital where he was pronounced dead.