The Maryland Department of Transportation says that U.S. Route 50 is closed in both directions in Wicomico County.
The closure is due to a crash involving a tractor-trailer rollover along westbound Route 50 between Rockawalkin Road.and White Lowe Road.
The truck reportedly rolled over and struck a guardrail.
The tractor-trailer is believed to be full of a flammable substance, so the Maryland Department of Environment is being called into remove the truck and clear the highway.
Hazmat crews are on the scene and officials say the highway could be closed until at least 6 p.m.
Motorists should use caution in the area and expect delays and detours.